203 research outputs found

    Halo Formation in Spheroidal Bunches with Self-Consistent Stationary Distributions

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    A new class of self-consistent 6-D phase space stationary distributions is constructed both analytically and numerically. The beam is then mismatched longitudinally and/or transversely, and we explore the beam stability and halo formation for the case of 3-D axisymmetric beam bunches using particle-in-cell simulations. We concentrate on beams with bunch length-to-width ratios varying from 1 to 5, which covers the typical range of the APT linac parameters. We find that the longitudinal halo forms first for comparable longitudinal and transverse mismatches. An interesting coupling phenomenon - a longitudinal or transverse halo is observed even for very small mismatches if the mismatch in the other plane is large - is discovered.Comment: 3 pages, 3 figures; presented at European Particle Accelerator Conference, Stockholm, Sweden (June 22-26, 1998

    Inclusion of Evaporation Physics in the Modeling of Water Availability in the Savannah River Basin

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    2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen

    Stationkeeping, Orbit Determination, and Attitude Control for Spacecraft in Near Rectilinear Halo Orbits

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    Final document is attached. From a Near Rectilinear Halo Orbit (NRHO), NASA's Gateway at the Moon is planned to serve as a proving ground and a staging location for human missions beyond Earth. Stationkeeping, Orbit Determination (OD), and attitude control are examined for uncrewed and crewed Gateway configurations. Orbit maintenance costs are investigated using finite maneuvers, considering skipped maneuvers and perturbations. OD analysis assesses DSN tracking and identifies OD challenges associated with the NRHO and crewed operations. The Gateway attitude profile is simulated to determine an effective equilibrium attitude. Attitude control propellant use and sizing of the required passive attitude control system are assessed

    Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Müller glia proliferation during zebrafish retinal regeneration

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    Intense light exposure causes photoreceptor apoptosis in dark-adapted adult albino zebrafish (Danio rerio). Subsequently, Müller glia increase expression of the Achaete-scute complex-like 1a (Ascl1a) and Signal transducer and activator of transcription 3 (Stat3) transcription factors and re-enter the cell cycle to yield undifferentiated neuronal progenitors that continue to proliferate, migrate to the outer nuclear layer, and differentiate into photoreceptors. A proteomic analysis of light-damaged retinal homogenates, which induced Müller glia proliferation when injected into an undamaged eye, revealed increased expression of tumor necrosis factor α (TNFα) signaling proteins relative to undamaged retinal homogenates. TNFα expression initially increased in apoptotic photoreceptors and later in Müller glia. Morpholino-mediated knockdown of TNFα expression before light damage diminished the expression of both Ascl1a and Stat3 in Müller glia and significantly reduced the number of proliferating Müller glia without affecting photoreceptor cell death. Knockdown of TNFα expression in the Müller glia resulted in fewer proliferating Müller glia, suggesting that Müller glial-derived TNFα recruited additional Müller glia to re-enter the cell cycle. While TNFα is required for increased Ascl1a and Stat3 expression, Ascl1a and Stat3 are both necessary for TNFα expression in Müller glia. Apoptotic inner retinal neurons, resulting from intravitreal injection of ouabain, also exhibited increased TNFα expression that was required for Müller glia proliferation. Thus, TNFα is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Müller glia to proliferate in the zebrafish retinal regeneration response. © 2013 the authors
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